» Hassner A., Stumer C. - Organic syntheses based on name reactions and unnamed reactions
Hassner A., Stumer C. - Organic syntheses based on name reactions and unnamed reactions
||Organic syntheses based on name reactions and unnamed reactions
||Hassner A., Stumer C.
||The above are the opening words of Exodus, the second book of the Petateuch. Already in ancient times, names were important in association with events. As organic chemistry developed during the 20th century, researchers started associating synthetically useful reactions with the names of discoverers or developers of these reactions. In many cases such names serve merely as a mnemonic, to remember a reaction more easily; there are few chemistry undergraduates who do not know what the Friedel-Crafts reaction is.
In recent years there has been a proliferation of new reactions and reagents that have been so useful in organic synthesis that often people refer to them by name. Many of these are stereoselective or regioselective methods. While the expert may know exactly what the Makosza vicarious nucleophilic substitution, or the Meyers asymmetric synthesis refers to, many students as well as researchers would appreciate guidance regarding such "Name Reactions".
It is in this context that we perceived the necessity to incorporate the older name reactions with some newer name reactions or "unnamed reactions", that are often associated with a name but for which details, references and experimental details are not at everyone's fingertips. This was our inspiration for the current monograph "Organic Syntheses based on Name Reactions and Unnamed Reactions".
In particular we thought it would be useful to include cross-references of functional group transformations and an experimental procedure, so that the reader will be able to evaluate the reaction conditions at a glance; for instance is this reaction carried out at room temperature or at 200'C? For 1 h or 5 days? Are special catalysts required? How is the reaction worked up, what yield can be expected?
The choice of which reactions to include is not an easy one. First there are the well known "Name Reactions", that have appeared in various monographs or in the old Merck index. Some of these are so obvious mechanistically to the modern organic chemistry practitioner that we have in fact omitted them; for instance esterification of alcohols with acid chlorides - the Schotten-Baumann procedure. Others are so important and so well entrenched by name, like the Baeyer-Villiger ketone oxidation, that it is impossible to ignore them. In general we have kept older name reactions that are not obvious at first glance.